8:30 - 12:00 - Register and Poster

9:00 - 9:30 - Coffee Break

10:30 – Transfer from Hotel to UNIFESP (speakers)

12:00 - 12:30 – Opening Chair João Bosco Pesquero (Brazil)

12:30 - 13:10 – Opening Lecture - "Two mouse tales"
Oliver Smithies (USA) – Nobel Prize in Physiology or Medicine 2007

13:10 - 15:00 – Lunch

15:00 - 18:00 - Session I: Techniques for the generation of transgenic animals

15:00 - 15:40 - Lecture 1
Generating knockouts e knockins by homologous recombination in mouse ES cells - Marcelo Rubinstein (Argentina)

15:40 - 16:20 - Lecture 2
The power of ES cell-mediated genetics- Andras Nagy (Canada)

16:20 - 16:40 - Coffee Break

16:40 - 17:20 - Lecture 3
Lentivirus-mediated transgenesis as a first cost-effective alternative to genome manipulation) - Jose Eduardo Krieger (Brazil)

17:20 - 18:00 - Lecture 4
Transgenesis with large genomic constructs: the use of BACs and YACs in mice – Lluis Montoliu (Spain)

18:00 - 19:00 – Poster Session / Happy Hour

19:00 – Transfer to Hotel (speakers)

20:00 – Symposium Opening Dinner

8:45 – Transfer from Hotel to UNIFESP (speakers)

9:00 - 11:20 - Session I: Techniques for the generation of transgenic animals

9:00 - 9:40 - Lecture 5
Applications of transposons for vertebrate transgenesis - Aron Geurts (USA)

9:40 - 10:20 - Lecture 6
Spermatogonial cell-mediated gene transfer – Natalia Alenina (Germany)

10:20 - 10:40 - Coffee Break

10:40 - 11:20 - Lecture 7
Positional cloning of mouse mutations: from mapping to gene identification – Jean Louis Guénet (France)

11:20 - 15:10 - Session II: Transgenesis in other species

11:20 - 12:00 - Lecture 8
Rat transgenesis – Michael Bader (Germany)

12:00 - 12:40 - Lecture 9
Production and use of transgenic birds - Denise Calisto Bongalhardo (Brazil)

12:40 - 14:30 - Lunch

14:30 - 15:10 - Lecture 10
Production of recombinant human coagulation factor IX in the milk of genetically modified mice - Elibio Rech (Brazil)

15:10 - 16:50 - Session III: Cloning

15:10 - 15:50 - Lecture 11
Animal cloning - Rodolfo Rumpf (Brazil)

15:50 - 16:30 - Lecture 12
Rat cloning – Elena Popova (Germany)

16:30 - 16:50 - Coffee Break

16:50 - 18:10 - Session IV: Ethics and Biosafety in Transgenesis

16:50 - 17:30 - Lecture 13
Ethics in the use of transgenic animal - Mirian Ghiraldini (Brazil)

17:30 - 18:10 - Lecture 14
Biosafety in animal experimentation: adapting animal handling to the new technologies - Yara Barreira (France)

18:10 - 19:00 - Poster Session / Happy Hour

19:00 – Transfer to Hotel (speakers)

20:30 - Dinner

8:45 - Transfer from Hotel to UNIFESP (speakers)

9:00 - 18:00 - Session V: Applications of Transgenic Animals

9:00 - 9:40 - Lecture 15
Use of transgenic animals for production of recombinant proteins - Louis-Marie Houdebine (France)

9:40 - 10:20 - Lecture16
Transgenic fish as bioreactors - Heden Luiz (Brazil)

10:20 - 10:40 - Coffee Break

10:40 - 11:20 - Lecture 17
Production of transgenic sheeps for the hG-CSF (human Granulocyte Colony Stimulating Factor): the Brazilian model – Vicente Freitas (Brazil)

11:20 - 12:00 - Lecture 18
ENU-gene driven mutagenesis as an interesting alternative to in vitro genetic engineering of ES cells – Jean-Louis Guénet (France)

12:00 - 12:40 - Lecture 19
iRNA biomedical applications – Iscia Terezinha Lopes Cendes (Brazil)

12:40 - 14:30 - Lunch

14:30 - 15:50 - Session VI: Patent and Alimentos produzidos de Animais Transgênicos

14:30 - 15:10 - Lecture 20
Patent and transgenics - Ricardo Amaral Remer (Brazil)

15:10 - 15:50 - Lecture 21
Codex Alimentarius and food production from genetically modified animals - Marília Regini Nutti (Brazil)

15:50 - 16:10 - Coffee Break

16:10 - 16:50 - Lecture 22
International Society for Transgenic Technologies - Lluis Montoliu (Spain)

16:50 - 17:20 - Lecture 23
Oral Presentation

17:20 - 18:00 - Lecture 24
Oral Presentation

18:00 - 19:00 - Cocktail Party

19:00 – Transfer to Hotel (speakers)

20:30 - Symposium Closing Dinner